Most of the microorganisms in the level of his life in a certain activity is influenced by other microorganisms. The influence of these may occur either directly or indirectly. One of the ants Although the triumphant discovery of antibiotics have passed, began in 1939 until 1959, but research in this rise again since 1965 with the discovery of antibiotics semisintetic such as β-laktamin. The present time, biotechnology antibiotics directed to find new antibiotics with microbes exploit the world, flute explore a diverse habitat of a diverse, channel selection and genetic improvement, technique media and culture, molecular biosynthesis, physiology and antibiotic production optimization, and fermentation industry model. Besides, encouraged the search for antibiotics can overcome AIDS, HIV and hepatitis B virus (Sudirman, 1994).
One of the organism of antibiotics that are now much discussed this is endofit fungi. Fungi endofit usually found in a network system, such as leaves, branches, roots or plants. Fungi can infect healthy plants on the network and is able to produce a certain micotocsic, enzyme and antibiotic (Carrol, 1988; Clay, 1988). Some association with the plants, fungi endofit wet nurse is able to protect plants from the mother several pathogenic virulent, both bacteria and fungi (Bills and Polyshook, 1992). agonist phenomenon antibiosis. In this case one of two populations of organisms that produce antibiotics compound.
Antibiotics are natural chemical substances of secondary metabolism microorganisms, which has hindered the ability of either growth or kill other microorganisms. The definition is very limited, because many molecules are now obtained through chemical synthesis, have activity against microorganisms. Now the term means all antibiotic substances that come from both natural and synthetic which have toxicities selective against one or more microorganisms goals, but have weak toxicities enough to wet nurse (human, animal or plant) and can be given through the public.
Although the triumphant discovery of antibiotics have passed, began in 1939 until 1959, but research in this rise again since 1965 with the discovery of antibiotics semisintetik such as β-laktamin. The present time, biotechnology antibiotics directed to find new antibiotics with microbes exploit the world, flute explore a diverse habitat of a diverse, channel selection and genetic improvement, technique media and culture, molecular biosynthesis, physiology and antibiotic production optimization, and fermentation industry model. Besides, encouraged the search for antibiotics can overcome AIDS, HIV and hepatitis B virus (Sudirman, 1994).
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